Przekazujemy Państwu informacje dotyczące 2 opublikowanych ostatnio opinii SCCS:
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SCCS/1589/17 Opinion on Skin Sensitisation Quantitative Risk Assessment for Fragrance Ingredients (QRA2) – Submission I
W konkluzjach opinii czytamy:
In light of the methodology provided, does the SCCS consider QRA2 adequate to establish a concentration at which induction of sensitisation by a fragrance ingredient unlikely to occur?
The “QRA2 final report” together with the supplementary information received shows that a lot of progress has been achieved since the initial publication of the QRA. However, it is not yet possible to use the QRA2 to establish a concentration at which induction of sensitisation of fragrance is unlikely to occur. Several aspects of the methodology are not clear and the scientific rationale behind the methodology needs to be better described. These aspects have been highlighted in this Opinion.
Does the SCCS have any further scientific comments with regard to the use of QRA2 methodology to determine, in particular regarding applicability, development and improvements?
A number of additional considerations and refinements have been incorporated to the proposed methodology. However, explanation of certain methodological approaches and assumptions, as well as a description of uncertainties is lacking, the provision of which would enhance understanding of the methodology. These aspects have been highlighted in the SCCS comments under each section with the aim to provide pointers for improvement. If shaped up properly, this could be a useful methodology not only for risk assessment of fragrance allergens, but potentially also for other cosmetic ingredients.
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SCCS/1594/18 Opinion on the safety of cosmetic ingredient Phenylene Bis-Diphenyltriazine (CAS No 55514-22-2) – S86 – Submission II
W konkluzjach opinii czytamy:
In light of the new data provided, does the SCCS consider Phenylene Bis-Diphenyltriazine, S86 safe for use as a UV-filter in sunscreen products in a concentration up to 5.0%?
Based on the data provided in the dossier, the SCCS considers Phenylene BisDiphenyltriazine, S86, safe for use as a UV-filter in sunscreen products at a concentration up to 5%.
Because of the insoluble nature of S86 and as no data were provided on safety via inhalation exposure, the SCCS considers its use safe only in dermally applied products and not in products that would lead to inhalation exposure.
Does the SCCS have any further scientific concerns with regard to the use of Phenylene Bis-Diphenyltriazine, S86 as a UV-filter in sunscreen and/or other cosmetic products?
Phenylene Bis-Diphenyltriazine (S86) may contain impurities (NMP and hydrazine), which are classified as CMR 1B and identified in the EU as SVHC. Therefore, the level of NMP and hydrazine should be kept at trace levels.
Potential effects of Phenylene Bis-Diphenyltriazine (S86) on the environment have not been assessed by SCCS.
